A vehicle body structure is configured in such a manner that a left center pillar is covered with a left pillar garnish and a left gusset is joined to the upper end of the left center pillar. The left center pillar is provided with a pillar bead protruding toward the outside of a vehicle compartment. The left gusset is provided with a gusset bead that protrudes toward the vehicle compartment along the pillar bead. The gusset bead and the pillar bead form a first closed cross-section. An engagement section that is insertable into a first opening of the first closed cross-section is provided at the upper end of the left pillar garnish.