Invention Grant
- Patent Title: Aryl ethers and uses thereof
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Application No.: US15805390Application Date: 2017-11-07
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Publication No.: US10144711B2Publication Date: 2018-12-04
- Inventor: Darryl David Dixon , Jonas Grina , John A. Josey , James P. Rizzi , Stephen T. Schlachter , Eli M. Wallace , Bin Wang , Paul Wehn , Rui Xu , Hanbiao Yang
- Applicant: Peloton Therapeutics, Inc.
- Applicant Address: US TX Dallas
- Assignee: PELOTON THERAPEUTICS, INC.
- Current Assignee: PELOTON THERAPEUTICS, INC.
- Current Assignee Address: US TX Dallas
- Agency: Wilson Sonsini Goodrich & Rosati
- Main IPC: A61P35/00
- IPC: A61P35/00 ; A61K41/00 ; A61K31/09 ; C07C43/29 ; C07C43/275 ; C07D213/85 ; C07C43/285 ; C07C43/205 ; C07C43/263 ; C07C43/23 ; C07C43/225 ; A61K31/10 ; C07C255/54 ; C07C255/56 ; C07C205/22 ; C07C311/29 ; C07C313/06 ; C07C317/22 ; C07C317/24 ; C07C317/32 ; C07C317/34 ; C07C317/36 ; C07C317/40 ; C07C317/42 ; C07C317/44 ; C07C317/46 ; C07C317/48 ; C07C323/22 ; C07C381/10 ; C07D213/89 ; C07D231/56 ; C07D213/65
Abstract:
The present disclosure relates to HIF-2α inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2α scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice in vivo.
Public/Granted literature
- US20180155279A1 ARYL ETHERS AND USES THEREOF Public/Granted day:2018-06-07
Information query
IPC分类:
| A | 人类生活必需 |
| A61 | 医学或兽医学；卫生学 |
| A61P | 化合物或药物制剂的特定治疗活性 |
| A61P35/00 | 抗肿瘤药 |
