Invention Grant
- Patent Title: Piperazine derivatives as liver X receptor modulators
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Application No.: US15502356Application Date: 2015-08-04
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Publication No.: US10144715B2Publication Date: 2018-12-04
- Inventor: David A. Claremon , Chengguo Dong , Yi Fan , Katerina Leftheris , Stephen D. Lotesta , Suresh B. Singh , Colin M. Tice , Wei Zhao , Yajun Zheng , Linghang Zhuang
- Applicant: Vitae Pharmaceuticals, Inc.
- Applicant Address: US NJ Madison
- Assignee: Vitae Pharmaceuticals, Inc.
- Current Assignee: Vitae Pharmaceuticals, Inc.
- Current Assignee Address: US NJ Madison
- Agency: McCarter & English, LLP
- Agent Steven G. Davis; Michael J. DeGrazia
- International Application: PCT/US2015/043538 WO 20150804
- International Announcement: WO2016/022521 WO 20160211
- Main IPC: C07D241/04
- IPC: C07D241/04 ; C07D403/04 ; C07D413/14 ; C07D401/04 ; C07D401/06 ; C07D403/14 ; C07D405/06 ; C07D413/04 ; C07D417/04 ; C07D417/14 ; C07D497/04 ; C07D513/04
Abstract:
Provided are novel compounds of Formula (I): pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are liver X receptor modulators, and which are useful in the treatment of diseases and disorders associated with the liver X receptor. Also provided are the compounds of Formula (I) and pharmaceutical compositions thereof for treating atherosclerosis, cardiovascular disease, Alzheimer's disease, dermatitis, dyslipidemia, cancer and other diseases or disorders.
Public/Granted literature
- US20170226067A1 PIPERAZINE DERIVATIVES AS LIVER X RECEPTOR MODULATORS Public/Granted day:2017-08-10
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