Invention Grant
![Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors](/docs/US/2018-12-04/US10144739B2/abs.jpg.600x600.jpg)
- Patent Title: Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors
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Application No.: US15287958Application Date: 2016-10-07
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Publication No.: US10144739B2Publication Date: 2018-12-04
- Inventor: Andreas Gollner , Joachim Broeker , Nina Kerres , Christiane Kofink , Juergen Ramharter , Harald Weinstabl
- Applicant: Boehringer Ingelheim International GmbH
- Applicant Address: DE Ingelheim am Rhein
- Assignee: Boehringer Ingelheim International GmbH
- Current Assignee: Boehringer Ingelheim International GmbH
- Current Assignee Address: DE Ingelheim am Rhein
- Agent Edouard G. Lebel
- Priority: EP15189210 20151009
- Main IPC: C07D487/22
- IPC: C07D487/22 ; C07D471/22 ; A61K31/4162 ; A61K31/437 ; A61P35/00 ; A61K31/5377 ; A61K45/06 ; A61K31/4545
![Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors](/abs-image/US/2018/12/04/US10144739B2/abs.jpg.150x150.jpg)
Abstract:
The present invention encompasses compounds of formula (I) wherein the groups R1 to R4, R7, A, D, E, F, V, W, X, Y, n, r and q are defined in claim 1, their use as inhibitors of MDM2-p53 interaction, pharmaceutical compositions which contain compounds of this kind, their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases, and synthetic intermediates.
Public/Granted literature
- US20170174695A1 NEW SPIRO[3H-INDOLE-3,2'-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS Public/Granted day:2017-06-22
Information query
