When a USB device that supports multiple streams is redirected, a multi-channel environment can be established in which each USB stream is associated with a separate network connection. As a result, each USB stream will be transferred over the network in its own connection and therefore the data transfer can be carried out in an out-of-order fashion and with speeds that better approximate those provided by the USB SuperSpeed feature. To handle the routing of URBs to the appropriate network connection, the virtual desktop infrastructure can implement a lookup table to associate a stream's handle with a particular network connection.