The present invention provides a method and an apparatus for handling full-duplex interference. One method includes: obtaining an interference degree that is caused when a site device performs full-duplex transmission with at least two UEs; and determining, according to the interference degree, a UE allowed to transmit uplink and downlink signals on the same time and frequency resource among the at least two UEs. In embodiments of the present invention, a UE allowed to transmit uplink and downlink signals on the same time and frequency resource may be classified according to an interference degree that is caused when a site device performs full-duplex transmission with at least two UEs, thereby preventing the interference problem in the scenario of point-to-multipoint full-duplex communication as much as possible.