A method of managing instruction execution for multiple instruction streams using a processor core having multiple parallel instruction execution slices. An event is detected indicating that either resource requirement or resource availability for a subsequent instruction of an instruction stream will not be met by the instruction execution slice currently executing the instruction stream. In response to detecting the event, dispatch of at least a portion of the subsequent instruction is made to another instruction execution slice. The event may be a compiler-inserted directive, may be an event detected by logic in the processor core, or may be determined by a thread sequencer. The instruction execution slices may be dynamically reconfigured as between single-instruction-multiple-data (SIMD) instruction execution, ordinary instruction execution, wide instruction execution. When an instruction execution slice is busy processing a current instruction for one of the streams, another slice can be selected to proceed with execution.