A method is provided for determining a navigation image displaying features of a region of interest of a patient, (e.g., used during a medical intervention). The method includes determining a first subtraction image by recording a first X-ray image with an X-ray device and subtracting a mask image. The method also includes determining a second subtraction image by recording a second X-ray image with the X-ray device and by subtracting the mask image or a further mask image. Additionally, the navigation image is determined by superimposing the first and the second subtraction image. At least one of the subtraction images is preprocessed before the superimposition by transfer from a gray-value space into a color space that is different from a color space of the other subtraction image. The navigation image is determined in color and/or the dynamics of at least one of the subtraction images are compressed.