A display substrate, a display equipment and a regional compensation method. The display substrate includes a pixel array, a common cathode current detection circuit, and a data signal compensation circuit. The common cathode current detection circuit is configured to detect a total current flowing through each common cathode; the data signal compensation circuit is configured to receive the pixel light emitting current of the first sub-pixel, receive the total current of the common cathode, and calculate compensation data for each of the sub-pixels according to the pixel light emitting current and the total current of the common cathode.