This disclosure provides wearable-device based user-interested information determination methods, apparatuses and wearable devices. The method includes: receiving, by an electrocardiography (ECG) sensor associated with the wearable device, an ECG signal of a user, determining a feature set for the ECG signal, in which the feature set includes time-domain feature data of the ECG signal and frequency-domain feature data of the ECG signal, and determining the user-interested information based on similarity between the feature set and reference feature sets indicative of the user-interested information, in which the user-interested information includes health information associated with a disease. The wearable device includes an ECG sensor configured to receive an ECG signal and an FPGA system. The FPGA system includes modules for determine user-interested information based on the ECG signal. The apparatus includes a processor and a memory coupled to the processor. The memory is configured to store instructions to implement the method.