An information processing system includes a storage unit that stores association information that is obtained by associating identifying information of a plurality of second communication networks that are interconnected via a first communication network with identifying information of a virtual device that exists in the second communication network; a first specifying unit that specifies according to the association information a second communication network in which a target virtual device exists, in a case in which the first specifying unit acquires a request for a setting change to the target virtual device; a second specifying unit that specifies a physical server on which the target virtual device runs from among physical servers that exist in the specified second communication network; and a setting unit that performs the setting change to the target virtual device that runs on the specified physical server.