The present disclosure generally relates to systems for disinfecting Central Venous Catheter (CVC) system ports that use highly-abrasive and highly-conforming foam material in place of wipes or other sponge products, and methods for using such systems. The foam material may be an open-cell microabrasive material such as melamine foam. The foam material may contain disinfecting solutions such as isopropyl alcohol, chlorhexidine gluconate, or povidone-iodine.