- Patent Title: AAV mediated aquaporin gene transfer to treat Sjogren's syndrome
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Application No.: US14423774Application Date: 2013-08-30
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Publication No.: US10166299B2Publication Date: 2019-01-01
- Inventor: John Chiorini
- Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES
- Applicant Address: US DC Washington
- Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPT. OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH
- Current Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPT. OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH
- Current Assignee Address: US DC Washington
- Agency: Fox Rothschild LLP
- International Application: PCT/US2013/057632 WO 20130830
- International Announcement: WO2014/036468 WO 20140306
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C12N15/86 ; C07K14/705 ; C07K14/47 ; A61K38/17
Abstract:
The invention relates to a gene transfer-based method to protect a subject from Sjogren's syndrome. The method comprises administering to the subject an AAV virion comprising an AAV vector that encodes aquaporin-1 (AQP-1) protein. Also provided are AQP-1 proteins and nucleic acid molecules that encode such proteins. Also provided are AAV vectors and AAV virions that encode an AQP-1 protein.
Public/Granted literature
- US20150203553A1 AAV MEDIATED AQUAPORIN GENE TRANSFER TO TREAT SJOGREN'S SYNDROME Public/Granted day:2015-07-23
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