Methods and systems for configuring a manual and/or automated processing system to conform to a contoured surface of a structure are disclosed. One example includes an automated processing system with a flexible rail configuration. One or more turnbuckles and/or other actuators configure and hold the flexible rail configuration into conformity with the surface (which could be flat or of a curvature) during processing by the automated processing system. Additionally, one or more combination suction-cup pressurized-air devices may be coupled to the flexible rail configuration for selectively attaching the flexible rail configuration to the contoured surface and also for selectively releasing and/or facilitating elevation and movement of the flexible rail configuration above and about the contoured surface. A multi-function end effector may be associated with the flexible rail configuration and be moveable relative thereto.