A reusable closure system is disclosed for packaging applications. The closure system generally includes a base and hinged lid. The base is bondable to a package and includes a field of touch fasteners having one or more cut-lines therein defining a hinged pull-tab assembly. The lid includes a complementary touch fastener field and can be placed in the open position to expose the pull-tab assembly, which can then be peeled back to open the package by virtue of the bond between the pull-tab assembly and a frangible region in the package. After opening, the pull-tab assembly can be stowed to the lid, so as to provide a lid-based plug corresponding to the package hole. Optional tamper-evident elements allow a consumer to see the package has not yet been opened. Stay-open lid and anti-peel mechanisms may also be provided. A dispensable roll/fanfold of the closures can feed a flow-wrap packaging process.