Invention Grant
- Patent Title: Allosteric inhibitors of proteasome and methods of use thereof
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Application No.: US14896984Application Date: 2014-06-13
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Publication No.: US10167259B2Publication Date: 2019-01-01
- Inventor: Pawel A. Osmulski , Maria E. Gaczynska
- Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
- Applicant Address: US TX Austin
- Assignee: The Board of Regents of the University of Texas System
- Current Assignee: The Board of Regents of the University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Parker Highlander PLLC
- International Application: PCT/US2014/042383 WO 20140613
- International Announcement: WO2014/201405 WO 20141218
- Main IPC: C07D211/60
- IPC: C07D211/60 ; A61K45/06 ; A61K31/69 ; C07D401/12 ; C07D413/12 ; C07D498/08
Abstract:
The present invention relates generally to novel allosteric regulators of proteasome activity, methods for preparation and use, and pharmaceutical compositions thereof. Specifically piperidine-2-carboxylic acid derivatives containing 1-oxo-aroyl group and a lipophilic ester side chain are disclosed as allosteric inhibitors of proteasome 2S activity, and as therapeutic agents for the treatment of proteasome-associated disorders in a subject.
Public/Granted literature
- US20160152567A1 NOVEL ALLOSTERIC INHIBITORS OF PROTEASOME AND METHODS OF USE THEREOF Public/Granted day:2016-06-02
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