Invention Grant
- Patent Title: Sodium channel blockers
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Application No.: US15336574Application Date: 2016-10-27
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Publication No.: US10167266B2Publication Date: 2019-01-01
- Inventor: Michael R. Johnson
- Applicant: Parion Sciences, Inc.
- Applicant Address: US NC Durham
- Assignee: Parion Sciences, Inc.
- Current Assignee: Parion Sciences, Inc.
- Current Assignee Address: US NC Durham
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: A61K31/496
- IPC: A61K31/496 ; C07D241/28 ; C07D241/26 ; A61K31/4965 ; A61K31/497 ; A61K31/706 ; A61K45/06 ; C07D241/32 ; C07D405/12 ; C07H15/26
Abstract:
The present invention relates to compounds of Formula (I) and pharmaceutical compositions thereof. Compounds of Formula (I) are epithelial sodium channel (ENaC) blockers useful in the hydration of mucosal surfaces, enhancement of mucociliary clearance, or restoration of mucosal defense in a subject. The compounds and compositions can therefore be used to treat diseases which rely on the hydration of mucosal surfaces.
Public/Granted literature
- US20170267650A1 SODIUM CHANNEL BLOCKERS Public/Granted day:2017-09-21
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