Invention Grant
![Substituted pyrazino[2,3-b]pyrazines as mTOR kinase inhibitors](/docs/US/2019-01-01/US10167290B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted pyrazino[2,3-b]pyrazines as mTOR kinase inhibitors
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Application No.: US15680688Application Date: 2017-08-18
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Publication No.: US10167290B2Publication Date: 2019-01-01
- Inventor: Jan Elsner , Roy L. Harris , Branden Gingsee Lee , Deborah Mortensen , Garrick K. Packard , Patrick Papa , Jason Parnes , Sophie Perrin-Ninkovic , Jennifer Riggs , John Sapienza , Graziella I. Shevlin , Lida Tehrani , Jingjing Zhao
- Applicant: SIGNAL PHARMACEUTICALS, LLC
- Applicant Address: US CA San Diego
- Assignee: Signal Pharmaceuticals, LLC
- Current Assignee: Signal Pharmaceuticals, LLC
- Current Assignee Address: US CA San Diego
- Agency: Jones Day
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D498/14 ; C07D241/20 ; C07D471/04 ; C07D471/14 ; C07D487/10 ; C07D487/14
![Substituted pyrazino[2,3-b]pyrazines as mTOR kinase inhibitors](/abs-image/US/2019/01/01/US10167290B2/abs.jpg.150x150.jpg)
Abstract:
Provided herein are methods for the preparation of substituted pyrazino[2,3-b]pyrazines of the formula (II): the method comprising contacting a compound of formula (VI): with R1—Y in a solvent, in the presence of a palladium catalyst, wherein said contacting occurs in the presence of a base, wherein R1-R3, Y, the palladium catalyst and the base are as defined herein.
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