Invention Grant
- Patent Title: Caged cell penetrating peptide-polymer conjugates for diagnostic and therapeutic applications
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Application No.: US13700847Application Date: 2011-05-26
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Publication No.: US10167319B2Publication Date: 2019-01-01
- Inventor: Ayelet David , Gonen Ashkenasy , Yosi Shamay
- Applicant: Ayelet David , Gonen Ashkenasy , Yosi Shamay
- Applicant Address: IL Beer-Sheva
- Assignee: Ben-Gurion University of Negev Research & Development Authority
- Current Assignee: Ben-Gurion University of Negev Research & Development Authority
- Current Assignee Address: IL Beer-Sheva
- Agency: Cooley LLP
- Agent Ivor R. Elrifi; Matthew Pavao
- International Application: PCT/IL2011/000413 WO 20110526
- International Announcement: WO2011/151814 WO 20111208
- Main IPC: A61K51/00
- IPC: A61K51/00 ; A61M36/14 ; C07K9/00 ; A61K47/48 ; A61K49/00 ; A61K47/32
Abstract:
The caged cell-penetrating peptide (cCPP) conjugates of this invention are ideal for intracellular delivery of a broad variety of cargoes including various nanoparticulate pharmaceutical carriers (liposomes, micelles, microparticles, nanoparticles, polymer-conjugates). The conjugates comprise a detectable agent or a therapeutic agent, and the conjugates provide a novel strategy for site-specific delivery of the same to appropriate tissues in the subject. Versatile application of the conjugates in diagnostics and imaging is described.
Public/Granted literature
- US20140017169A1 CAGED CELL PENETRATING PEPTIDE-POLYMER CONJUGATES FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS Public/Granted day:2014-01-16
Information query
