Invention Grant
- Patent Title: Cell-specific internalizing RNA aptamers against human CCR5 and uses therefore
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Application No.: US15469320Application Date: 2017-03-24
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Publication No.: US10167474B2Publication Date: 2019-01-01
- Inventor: John Rossi , Jiehua Zhou , Marc Weinberg , Kevin Morris
- Applicant: City of Hope , The Scripps Research Institute
- Applicant Address: US CA Duarte US CA La Jolla
- Assignee: City of Hope,The Scripps Research Institute
- Current Assignee: City of Hope,The Scripps Research Institute
- Current Assignee Address: US CA Duarte US CA La Jolla
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12N15/115
Abstract:
Provided herein are fluoropyrimidine-modified RNA aptamers capable of binding CCR5. The compositions and methods provided herein are, inter alia, useful for the delivery of antiviral drugs (e.g., siRNAs) and preventing HIV entry into a target cell.
Public/Granted literature
- US20180080026A1 CELL-SPECIFIC INTERNALIZING RNA APTAMERS AGAINST HUMAN CCR5 AND USES THEREFORE Public/Granted day:2018-03-22
Information query
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