An internal combustion engine comprises an exhaust purification catalyst. The control system comprises a temperature detecting means for detecting or estimating a temperature of the exhaust purification catalyst, performs feedback control so that an air-fuel ratio of exhaust gas flowing into the exhaust purification catalyst becomes a target air-fuel ratio, and performs target air-fuel ratio setting control which alternately sets the target air-fuel ratio to a rich set air-fuel ratio and a lean set air-fuel ratio. In addition, the control system increases a variation difference, obtained by subtracting a rich degree of the rich set air-fuel ratio from a lean degree of a lean set air-fuel ratio, when a temperature of the exhaust purification catalyst detected or estimated by the temperature detecting means is a predetermined upper limit temperature or less compared with when it is higher than the upper limit temperature. As a result, a sulfur ingredient storage amount of an exhaust purification catalyst is maintained low.