A system can include an actuator with a piston rod that displaces in response to pressure in the actuator, a seal assembly that seals about the piston rod and includes seal cartridges, each including a dynamic seal sealingly engaging the rod, and each including a static seal sealingly engaging a seal assembly housing, and a port providing communication between a housing exterior and a housing interior between adjacent static seals. A method can include preventing leakage from a well with a seal assembly about a piston rod of a hydraulic actuator, the seal assembly including seal cartridges, each including a dynamic seal that sealingly engages the rod, and each including a static seal that sealingly engages a seal assembly housing, enabling communication through a housing sidewall to a housing interior between adjacent static seals, and reciprocably displacing the rod in response to pressure variations in the actuator.