Invention Grant
- Patent Title: Devices for determining cell force properties and methods of manufacturing the devices
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Application No.: US14202946Application Date: 2014-03-10
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Publication No.: US10168341B2Publication Date: 2019-01-01
- Inventor: Wilbur A. Lam , David Myers , Yongzhi Qiu
- Applicant: EMORY UNIVERSITY , CHILDREN'S HEALTHCARE OF ATLANTA, INC.
- Applicant Address: unknown Atlanta US GA Atlanta
- Assignee: Emory University,Children's Healthcare of Atlanta, Inc.
- Current Assignee: Emory University,Children's Healthcare of Atlanta, Inc.
- Current Assignee Address: unknown Atlanta US GA Atlanta
- Agency: Emory Patent Group
- Main IPC: G01N21/75
- IPC: G01N21/75 ; B01L3/00 ; G01N33/86 ; G01N21/77

Abstract:
A device may be configured to allow individual measuring of at least one property of at least one cell, such as measuring a contraction force of a platelet. The device may include a plurality of wells. Each well may include a hydrogel layer, the hydrogel layer including a hydrogel having a top surface that includes a pattern of cell interaction regions. The wells may differ in stiffness properties of the hydrogel and/or biochemical conditions. Each cell interaction region may include a group of at least two cell interaction sites. The spacing between each cell interaction region may be greater than a spacing between the at least two cell interaction sites of each cell interaction region. In this way, cell-cell interactions may be reduced and thereby increasing number of individual cells capable of being measured.
Public/Granted literature
- US20140256033A1 DEVICES FOR DETERMINING CELL FORCE PROPERTIES AND METHODS OF MANUFACTURING THE DEVICES Public/Granted day:2014-09-11
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