The present disclosure is directed to power conservation via global navigation satellite system (GNSS)-cellular activity synchronization. In general, power may be conserved in a device by setting a GNSS module in a device to operate during a time period when communication resources (e.g., a communication module) in the device are already scheduled to operate, which may conserve power in the device. Synchronization may occur via a notification (e.g., a pulse, a message, etc.) that is transmitted from the communication module to the GNSS module. In this manner, the burden of managing GNSS module operation may be shifted from control resources in the device (e.g., a system module) to the communication module, allowing the system module to remain in a power conservation state (e.g., sleep state) for longer durations and for GNSS signal measurement to occur when the system module is already active.