Method and device for operating a touch screen are provided. The method includes that: a terminal obtains an actual sliding track of a touch operation of a user on a touch screen of the terminal (S102); the terminal replaces the actual sliding track with a pre-set sliding track corresponding to the actual sliding track (S104); and the terminal responds to a touch operation of the user according to the pre-set sliding track (S106). The present disclosure solves the problem in the prior art that a touch screen reports all false touches of a user over-sensitively and over-precisely, thereby facilitating a simple operation on the touch screen, reducing false and misinterpreted touches, and improving user experience.