Managing markup documents having a definition conforming to a pre-defined specification by retrieving the definition of a content markup document, the definition including a set of one or more content portions enclosed within a content element of semantically neutral type having a content identifier, retrieving the definition of a layout markup document, the definition including a set of layout elements of semantically neutral type each one having a layout identifier, and generating the definition of a combined markup document from the definition of the layout markup document and the definition of the at least one content markup page, where generating the definition of a combined markup document includes inserting the content portion enclosed within each content element of the content markup document into the definition of the layout markup document in correspondence of each layout element with the layout identifier matching the content identifier of the content element.