A method, system and computer program product perform timing analysis of an integrated circuit design with callback-based constraint processing for clock domain independence. A timing graph representation of the integrated circuit design includes nodes interconnected by edges. Loading timing abstracts representing the nodes of the timing graph precedes obtaining a timing result based on propagating timing values and associated timing tags from an input to an output of the integrated circuit design and processing timing constraints at one or more of the nodes as callbacks. Each timing tag indicates a clock domain. After applying a design change, one or more modified timing tags that are added or changed as a result of the design change are determined. The timing constraints associated with the modified timing tags are processed as callbacks, and the timing result are re-computed.