An imaging quality control system (80) employing an imaging quality controller (84) and a monitor (81). In operation, the imaging quality controller (84) executes an image processing of subject image data of the anatomical object (e.g., subject non-segmentation-based or segmentation-based image registration of US, CT and/or MRI anatomical images), and assessing an accuracy of the image processing of the subject image data of the anatomical object as a function of a subject Eigen weight set relative to a training Eigen range set (e.g., previously registered or segmented US, CT and/or MRI anatomical images). The subject Eigen weight set is derived from the subject image data of the anatomical object, and the training Eigen range set is derived from training image data of anatomical object. The monitor (81) displays the assessment of the accuracy of the image processing of the subject image data of the anatomical object by the imaging quality controller (84).