Methods, systems, and computer-readable media for monitoring a graphics processing unit (GPU) of a host computer system, including providing at least one test seed and at least one subsystem command to the GPU; receiving at least one test result from the GPU in response to providing the at least one test seed and at least one subsystem command to the GPU; and if the at least one test result does not correspond to at least one expected result, identifying the GPU as being in an undesired state. The subsystems to be tested may be a subset of all subsystems. The determination of subsystems to be tested may be determined in real-time, based on graphical application instructions. The subsystems to be tested may also be pre-determined.