A mura compensation method for display panel is disclosed, including: compressing on an array basis of n*m pixels, storing a default mura compensation value corresponding to a first pixel in each area; based on the default mura compensation value, performing linear interpolation calculation to obtain mura compensation values for pixels in the same area other than the first pixel, and performing mura compensation to the display panel; after performing mura compensation to the display panel, obtaining information of an X-th area still having mura phenomenon, the X-th area being an area formed by compression on an array basis of n*m pixels of the display panel; obtaining a final grayscale compensation curve equation; based on the default mura compensation value and the final grayscale compensation curve equation, calculating supplementary mura compensation values for pixels in the X-th area other than the first pixel; re-performing the mura compensation to the X-th area.