A four-level pulse amplitude modulation transmitter and corresponding method are provided. The transmitter includes a most significant bit processing section and a least significant bit processing section. The transmitter further includes at least one termination resistor connected to respective outputs of the processing sections to provide a transmitter output. Each of the processing sections include a set of retiming latches arranged in a parallel for aligning input parallel data and providing parallel aligned latched outputs responsive to one phase of a quarter-rate four-phase quadrature clock. Each of the processing sections further includes a serializer for serializing the parallel aligned latched outputs to provide a serialized output using quarter-rates of the quarter-rate four-phase quadrature clock. Each of the processing sections also include an output driver for driving the serialized output.