A staple cartridge assembly for use with a surgical stapling instrument is disclosed. The staple cartridge assembly comprises a plurality of staples and a cartridge body. The cartridge body comprises an elongate slot extending along a first longitudinal axis between a proximal end and a distal end of the cartridge body. The cartridge body further comprises a plurality of first staple cavities arranged in a first row. Each first staple cavity defines a first axis and comprises a first proximal end portion and a first distal end portion. The cartridge body further comprises a plurality of second staple cavities arranged in a second row. Each second staple cavity defines a second axis and comprises a second proximal end portion and a second distal end portion. Each first axis and each second axis are transverse to the first longitudinal axis. Each first axis is transverse to each second axis.