Drill guides and related methods are disclosed herein, e.g., for use in surgical procedures. In some embodiments, a drill guide can include an adjustment mechanism that permits one-handed adjustment of the guide depth and does not require that the drill guide be removed from the patient or that the drill be removed from the drill guide when making an adjustment. The adjustment mechanism can include a trigger that moves first and second detents into and out of engagement with a guide stem to allow step-wise adjustment of the guide depth.