Invention Grant
- Patent Title: RNA viruses for immunovirotherapy
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Application No.: US15247426Application Date: 2016-08-25
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Publication No.: US10172894B2Publication Date: 2019-01-08
- Inventor: Guy Ungerechts , Tobias Speck , Christine Engeland , Sascha Bossow
- Applicant: Deutsches Krebforschungszentrum , RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
- Applicant Address: DE DE
- Assignee: DEUTSCHES KREBSFORSCHUNGSZENTRUM,RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
- Current Assignee: DEUTSCHES KREBSFORSCHUNGSZENTRUM,RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
- Current Assignee Address: DE DE
- Agency: J.A. Lindeman & Co., PLLC
- Priority: JP2015-166899 20150826
- Main IPC: A61K35/768
- IPC: A61K35/768 ; C07K16/28 ; C07K16/30 ; C12N5/0783 ; C12N7/00 ; A61K48/00

Abstract:
The present invention relates to a recombinant virus of the family Paramyxoviridae, comprising at least one expressible polynucleotide encoding a multispecific binding polypeptide, said multispecific binding polypeptide comprising a first binding domain binding to a surface molecule of an immune cell with antitumor activity, preferably a lymphocyte, more preferably a T cell or a dendritic cell, and a second binding domain binding to a tumor-associated antigen; to a polynucleotide encoding the same, and to a kit comprising the same. Moreover, the present invention relates to a method for treating cancer in a subject afflicted with cancer, comprising contacting said subject with a recombinant virus of the family Paramyxoviridae of the invention, and thereby, treating cancer in a subject afflicted with cancer.
Public/Granted literature
- US20170128505A1 RNA VIRUSES FOR IMMUNOVIROTHERAPY Public/Granted day:2017-05-11
Information query
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