Invention Grant
- Patent Title: Orally disintegrating solid pharmaceutical dosage unit containing a partus control substance
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Application No.: US15516127Application Date: 2015-09-29
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Publication No.: US10172913B2Publication Date: 2019-01-08
- Inventor: Johannes Jan Platteeuw , Herman Jan Tijmen Coelingh Bennink
- Applicant: Oxytone Bioscience B.V.
- Applicant Address: NL Zeist
- Assignee: Oxytone Bioscience B.V.
- Current Assignee: Oxytone Bioscience B.V.
- Current Assignee Address: NL Zeist
- Agent Gilberto M. Villacorta; Sunit Talapatra
- Priority: EP14187354 20141001
- International Application: PCT/NL2015/050673 WO 20150929
- International Announcement: WO2016/053091 WO 20160407
- Main IPC: A61K31/11
- IPC: A61K31/11 ; A61K38/11 ; A61K9/00 ; A61K9/16 ; A61K9/20

Abstract:
An orally disintegrating solid pharmaceutical dosage unit having a weight between 50 and 1,000 mg is disclosed. The dosage unit consists of: (a) 5-100 wt. % of coated particles comprising 50-99 wt. % of a core particle and 1-50 wt. % of a coating that envelops the core particle, said coating consisting of: 0.01-10 wt. % of a partus control substance selected from oxytocin, carbetocin, atosiban and combinations thereof; 5-50 wt. % of buffering agent; 15-80 wt. % of branched glucan; 0-78 wt. % of other pharmaceutically acceptable ingredients; and (b) 0-95 wt. % of one or more pharmaceutically acceptable excipients; the solid dosage unit comprising at least 20 μg of the partus control substance and having a pH buffer range of 3.5-5.7.
Public/Granted literature
- US20170304394A1 ORALLY DISINTEGRATING SOLID PHARMACEUTICAL DOSAGE UNIT CONTAINING A PARTUS CONTROL SUBSTANCE Public/Granted day:2017-10-26
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