Invention Grant
- Patent Title: Method of treatment of malignant solid tumors with afucosylated anti-FGFR2IIIb antibodies
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Application No.: US15166798Application Date: 2016-05-27
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Publication No.: US10172937B2Publication Date: 2019-01-08
- Inventor: Thomas Harding , Kristen Pierce , Namrata Patil , Thomas Brennan , Julie Hambleton
- Applicant: Five Prime Therapeutics, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Five Prime Therapeutics, Inc.
- Current Assignee: Five Prime Therapeutics, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: McNeill Baur PLLC
- Main IPC: A61K33/24
- IPC: A61K33/24 ; A61K31/337 ; A61K31/513 ; A61K39/00 ; A61K39/395 ; C07K16/28 ; A61K45/06
Abstract:
The present invention provides antibodies that bind FGFR2IIIb, wherein the antibodies are afucosylated. The present invention provides compositions comprising antibodies that bind FGFR2IIIb, wherein at least 95% of the antibodies in the composition are afucosylated. In some embodiments, methods of treating cancer comprising administering afucosylated anti-FGFR2IIIb antibodies are provided.
Public/Granted literature
- US20160339100A1 AFUCOSYLATED ANTI-FGFR2IIIB ANTIBODIES Public/Granted day:2016-11-24
Information query
