The tire-changing machine (1) for trucks comprises a bearing frame (2), at least a work unit (3) associated with the frame (2), having at least a supporting element (4) for supporting a wheel which can be operated in rotation around a substantially horizontal first axis (5) and also having a balancing device (10) of the wheel, at least a tool (8) associated with the frame (2) for the removal of the wheel tire, at least one of the supporting element (4) and the tool (8) being mobile with respect to the other in the direction of reciprocal close/away movement and wherein the work unit (3) is connected mobile in rotation to the frame (2) around a second axis (12) of rotation, the supporting element (4) and the balancing device (10) rotating integrally to one another around the second axis (12).