Invention Grant
- Patent Title: Topical aqueous ophthalmic compositions containing a 1H-indole-1-carboxamide derivative and use thereof for treatment of ophthalmic disease
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Application No.: US14292082Application Date: 2014-05-30
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Publication No.: US10174006B2Publication Date: 2019-01-08
- Inventor: Malay Ghosh , Christopher Michael Adams , Stephanie Kay Dodd , Stephen Hedrick Poor
- Applicant: Novartis AG
- Applicant Address: CH Basel
- Assignee: NOVARTIS AG
- Current Assignee: NOVARTIS AG
- Current Assignee Address: CH Basel
- Agent Asha K. Nadipuram
- Main IPC: A61K31/55
- IPC: A61K31/55 ; A61K31/519 ; A61K31/506 ; A61K31/4439 ; A61K31/724 ; C07D403/12 ; C07D401/12 ; C07D403/14 ; C07D413/14 ; C07D471/04 ; C07D487/04 ; C07D495/04 ; C07D519/00 ; A61K9/00 ; A61K47/02 ; A61K47/10 ; A61K47/18 ; A61K47/26 ; A61K47/32 ; A61K47/34 ; A61K9/08 ; A61K47/38
Abstract:
The present invention is directed to the provision of a multi-dose topical ophthalmic composition containing a 1H-indole-1-carboxamide and use thereof for treatment of ophthalmic disease. More specifically the present invention is directed to a multi-dose aqueous ophthalmic composition (e.g., a solution, a suspension, an emulsion or the like) containing a 1H-indole-1-carboxamide (e.g., N-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6-((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide) and use thereof for treatment of an ophthalmic disease at the back of the eye such as age related macular degeneration (AMD).
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