Invention Grant
- Patent Title: Compositions and methods for modulating ATP2A2 expression
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Application No.: US14401214Application Date: 2013-05-16
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Publication No.: US10174323B2Publication Date: 2019-01-08
- Inventor: Arthur M. Krieg , Romesh Subramanian , James McSwiggen , Jeannie T. Lee
- Applicant: Translate Bio MA, Inc. , The General Hospital Corporation
- Applicant Address: US MA Boston US MA Lexington
- Assignee: The General Hospital Corporation,Translate Bio MA, Inc.
- Current Assignee: The General Hospital Corporation,Translate Bio MA, Inc.
- Current Assignee Address: US MA Boston US MA Lexington
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/US2013/041381 WO 20130516
- International Announcement: WO2013/173598 WO 20131121
- Main IPC: C12N15/113
- IPC: C12N15/113 ; A61K31/7125 ; A61K31/7115 ; A61K31/712 ; C07H21/00 ; C07H21/02 ; C07H21/04 ; C12N15/52
Abstract:
Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of ATP2A2. Further aspects provide compositions and kits comprising single stranded oligonucleotides for activating or enhancing expression of ATP2A2. Methods for modulating expression of ATP2A2 using the single stranded oligonucleotides are also provided. Further aspects of the invention provide methods for selecting a candidate oligonucleotide for activating or enhancing expression of ATP2A2.
Public/Granted literature
- US20150159160A1 COMPOSITIONS AND METHODS FOR MODULATING ATP2A2 EXPRESSION Public/Granted day:2015-06-11
Information query
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