An overpressure safety system for use with a distribution of pressurized fluid associated with hydrocarbon production operations includes a safety valve in fluid communication with a main bore of a fluid control manifold assembly. The safety valve has a blocking condition where the safety valve blocks a flow of pressurized fluid through the safety valve, and a venting condition where the safety valve provides a fluid flow path for the pressurized fluid at a set overpressure to pass through the safety valve. A valve member is moveable within the safety valve between a first position where a pressure side of the valve member blocks the flow of the pressurized fluid at a pressure below the set overpressure from passing through the safety valve, and a second position where the valve member provides a fluid flow path for the pressurized fluid at any pressure to pass through the safety valve.