Method for the operation of an internal combustion engine having a plurality of cylinders (11 to detect misfires. An exhaust gas sensor at the exhaust gas of every cylinder of the internal combustion engine measures at least one actual exhaust gas value individually for the respective cylinder, and the respective measured actual exhaust gas value is compared with a reference exhaust gas value to determine at least one cylinder-specific deviation between the reference exhaust gas value and the actual exhaust gas value for each of the cylinders. It is determined for every cylinder based on the cylinder-specific deviation or based on every cylinder-specific deviation whether or not misfires are occurring at the respective cylinder.