Provided are methods for testing aerosol material compatibility of various samples to disinfectants, decontaminates, and other such materials that are used as aerosols. A test is performed in a controlled environment, such as an aerosol chamber, using a specific set of test parameters representative of actual use of tested materials, such as dispensing parameters and exposure parameters. During the test, a test surface of the sample is exposed to an aerosol mist. Other surfaces may be protected. After exposure to the aerosol mist, the sample may be allowed to sit for a period of time. The sample is later cleaned and tested to determine effects of various materials in the mist on the sample. In some embodiments, some or all operations may be repeated for the same sample or different samples. The test parameters may be varied to determine compatibility limits.