Invention Grant
- Patent Title: Rapid method for measuring cytotoxicity in non-RI system
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Application No.: US15301256Application Date: 2015-03-30
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Publication No.: US10175229B2Publication Date: 2019-01-08
- Inventor: Yoshimasa Tanaka , Yuki Sakai , Satoshi Mizuta , Hiroshi Ueda
- Applicant: NAGASAKI UNIVERSITY
- Applicant Address: JP Nagasaki
- Assignee: NAGASAKI UNIVERSITY
- Current Assignee: NAGASAKI UNIVERSITY
- Current Assignee Address: JP Nagasaki
- Agency: Leydig, Voit & Mayer, Ltd.
- Priority: JP2014-073475 20140331
- International Application: PCT/JP2015/059838 WO 20150330
- International Announcement: WO2015/152111 WO 20151008
- Main IPC: C07D401/14
- IPC: C07D401/14 ; G01N33/58 ; G01N33/50 ; G01N21/64 ; C07D401/12 ; C07D213/79

Abstract:
The present invention aims to provide a novel compound for measuring cellular cytotoxicity or cell proliferation capacity accurately with high reproducibility, conveniently and rapidly, and a measurement method of cellular cytotoxicity or cell proliferation capacity by using the compound. The present invention relates to a compound represented by the formula (I): wherein R1 is a substituent, R2 and R3 are each an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group, Y is a substituent, n is an integer of 0-3, Z is a single bond, —O—, —S—, —SO—, —SO2—, or —NR4— (R4 is a hydrogen atom or a substituent), and A is an optionally substituted C1-6 alkylene group) or a salt thereof.
Public/Granted literature
- US20170016880A1 RAPID METHOD FOR MEASURING CYTOTOXICITY IN NON-RI SYSTEM Public/Granted day:2017-01-19
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