A computer implemented method for selecting breakpoints for cross-layer debugging is provided. The method includes receiving code comprising a plurality of layers, and executing a static analysis of the code to obtain a use-definition (UD) chain, alias information, and a parameter mapping for each of the plurality of layers. The method also includes determining a statement of the code that produces one of an error and a failure, and generating a table comprising a plurality of fields including a working statement field, watching variable field, and a watching function field. The method includes adding the determined statement to the working statement field and performing a cross-layer analysis includes identifying at least one used variable and its associated alias as watching variables from the added working statement, searching the code based on the watching variable field. The method includes generating cross-layer suspect code points based on the cross-layer analysis.