Embodiments of the present disclosure provide a method and apparatus for controlling brightness of an OLED screen. The method comprises: obtaining brightness of a first sub-pixel in an M-th column of pixels; obtaining brightness of a second sub-pixel; and increasing brightness of the first sub-pixel based on a difference in brightness between the second sub-pixel and the first sub-pixel, if brightness of the second sub-pixel is greater than that of the first sub-pixel.