An adaptive interference cancellation apparatus for cancelling a side lobe between neighboring cells installed in a repeater and capable of improving quality of a communication signal and preventing frequent handover by maintaining a serving base station signal among repeater signals and cancelling an interference signal from a neighboring cell is provided. The adaptive interference cancellation apparatus for a side lobe between neighboring cells, which is installed in a mobile communication repeater system comprising an omni-directional antenna, includes: three directional antennas installed around the omni-directional antenna; an output signal selector configured to select and output two of three directional antenna incident signals; and an adaptive noise canceller configured to adaptively filter the two directional antenna incident signals output from the output signal selector, estimate a noise reference signal, and extract a serving base station signal by subtracting the estimated noise reference signal from an omni-directional antenna incident signal.