A method performed by radio network node for enabling channel handling of a channel between a wireless device and the radio network node in a wireless communication network. The channel is defined in continuous time and a sampling rate of the channel is non-uniform. The radio network node predicts a channel gain using a first sampling descriptor indicating a first momentary sampling frequency and a second sampling descriptor indicating a second momentary sampling frequency, wherein the first sampling descriptor operates on a different segment of continuous time than the second sampling descriptor. The predicted channel gain enables channel handling such as channel estimation and link adaptation.