Systems, methods, apparatuses, and software for operating content delivery networks are provided herein. In one example, a method of operating a domain name translation node in a first point-of-presence of a content delivery network is presented. The method includes receiving a translation message issued by an end user device for translation of a domain name into a content network address, and processing the translation message to identify a network address of a node that transferred the translation message. The method also includes selecting the content network address based at least in part on correlations between network addresses and performance factors to direct the end user device to a target cache node at a point-of-presence different than the point-of-presence of the domain name translation node, and transferring a response message indicating the content network address which directs the end user device to the target cache node at the second point-of-presence.