Invention Grant
- Patent Title: Methods for inhibiting expression of ASC, expression of NLRP3, and/or formation of NLRP3 inflammasome complex using diacerein or its analogs
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Application No.: US15238950Application Date: 2016-08-17
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Publication No.: US10195170B2Publication Date: 2019-02-05
- Inventor: Chih-Kuang Chen , Jing-Yi Lee , Wei-Shu Lu , Carl Oscar Brown, III
- Applicant: TWi Biotechnology, Inc.
- Applicant Address: TW Taipei
- Assignee: TWI Biotechnology, Inc.
- Current Assignee: TWI Biotechnology, Inc.
- Current Assignee Address: TW Taipei
- Agency: Wood, Phillips, Katz, Clark & Mortimer
- Main IPC: A61K31/192
- IPC: A61K31/192 ; A61K31/216
Abstract:
Methods and compositions for inhibiting expression of ASC, expression of NLRP3, and/or formation of NLRP3 inflammasome complex by using diacerein or its analogs are provided. Also provided are methods and compositions for the treatment and/or prevention of a disorder mediated by ASC and/or NLRP3, and/or by formation of NLRP3 inflammasome complex by using diacerein or its analogs.
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