Invention Grant
- Patent Title: Glucocorticoid-loaded nanoparticles for prevention of corneal allograft rejection and neovascularization
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Application No.: US15502732Application Date: 2015-08-03
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Publication No.: US10195212B2Publication Date: 2019-02-05
- Inventor: Justin Scot Hanes , Qing Pan , Qingguo Xu , Nicholas J. Boylan , Walter J. Stark , Bing Wang , Lixia Luo
- Applicant: The Johns Hopkins University
- Applicant Address: US MD Baltimore
- Assignee: The Johns Hopkins University
- Current Assignee: The Johns Hopkins University
- Current Assignee Address: US MD Baltimore
- Agency: Pabst Patent Group LLP
- International Application: PCT/US2015/043478 WO 20150803
- International Announcement: WO2016/025215 WO 20160218
- Main IPC: A61K31/573
- IPC: A61K31/573 ; A61K9/00 ; A61K31/00 ; A61K9/50 ; A61K9/51
Abstract:
Particles encapsulating a glucocorticoid such as dexamethasone sodium phosphate (DSP) into a matrix such as biodegradable poly(lactic-coglycolic acid) (PLGA) which is densely coated with hydrophilic polymer such as PEG or PLURONIC® F127, exhibit sustained release of DSP for up to 7 days in vitro. These nanoparticles can be used to prevent corneal graft rejection or corneal neovascularization.
Public/Granted literature
- US20170157147A1 GLUCOCORTICOID-LOADED NANOPARTICLES FOR PREVENTION OF CORNEAL ALLOGRAFT REJECTION AND NEOVASCULARIZATION Public/Granted day:2017-06-08
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